100000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 100020 - Disclosure - Balance Sheet Components - Summary of Available for Sale Securities in Unrealized Loss Position, Fair Value and Gross Unrealized Loss By Length of Time Security in Continual Unrealized Loss Position (Detail) 2 link:presentationLink link:calculationLink link:definitionLink 100030 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100040 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 100050 - Statement - Consolidated Statements of Operations (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100060 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 100070 - Statement - Consolidated Statements of Changes in Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 100080 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 100090 - Statement - Consolidated Statements of Cash Flows (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100100 - Disclosure - The Company link:presentationLink link:calculationLink link:definitionLink 100110 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 100120 - Disclosure - Collaboration Agreements,License Agreement and Revenues link:presentationLink link:calculationLink link:definitionLink 100130 - Disclosure - Equity Method Investment - Variable Interest Entity link:presentationLink link:calculationLink link:definitionLink 100140 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 100150 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 100160 - Disclosure - Balance Sheet Components link:presentationLink link:calculationLink link:definitionLink 100170 - Disclosure - Liability Related to Sale of Future Royalties link:presentationLink link:calculationLink link:definitionLink 100180 - Disclosure - Product Development Obligations link:presentationLink link:calculationLink link:definitionLink 100190 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 100200 - Disclosure - Equity and Stock-based Compensation link:presentationLink link:calculationLink link:definitionLink 100210 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 100220 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 100230 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 100240 - Disclosure - Segment and Geographic Information link:presentationLink link:calculationLink link:definitionLink 100250 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink 100260 - Disclosure - Schedule II - Valuation and Qualifying Accounts link:presentationLink link:calculationLink link:definitionLink 100270 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 100280 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 100290 - Disclosure - Collaboration Agreements, License Agreement and Revenues (Tables) link:presentationLink link:calculationLink link:definitionLink 100300 - Disclosure - Equity Method Investment - Variable Interest Entity (Tables) link:presentationLink link:calculationLink link:definitionLink 100310 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 100320 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 100330 - Disclosure - Balance Sheet Components (Tables) link:presentationLink link:calculationLink link:definitionLink 100340 - Disclosure - Liability Related to Sale of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 100350 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 100360 - Disclosure - Equity and Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 100370 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 100380 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 100390 - Disclosure - Segment and Geographic Information (Tables) link:presentationLink link:calculationLink link:definitionLink 100400 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100410 - Disclosure - Summary of Significant Accounting Policies - Schedule of Significant Balance of Accounts Receivable (Detail) link:presentationLink link:calculationLink link:definitionLink 100420 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100430 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Accounting for the Astellas Agreements - Additional Information 2 (Detail) link:presentationLink link:calculationLink link:definitionLink 100440 - Disclosure - Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Accounting for the AstraZeneca Agreements - Additional Information 3 (Detail) link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Eluminex Agreement - Additional Information 2 (Detail) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue (Detail) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Summary of Revenue Recognized Under the Collaboration Agreements - Additional Information 4 (Detail) link:presentationLink link:calculationLink link:definitionLink 100500 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations Deferred Revenue (Detail) link:presentationLink link:calculationLink link:definitionLink 100510 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations Deferred Revenue (Parenthetical) (Detail) link:presentationLink link:calculationLink link:definitionLink 100520 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Summary of Amounts Recognized as Revenue (Detail) link:presentationLink link:calculationLink link:definitionLink 100530 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Summary of Product Revenue, Net (Detail) link:presentationLink link:calculationLink link:definitionLink 100540 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) link:presentationLink link:calculationLink link:definitionLink 100550 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100560 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Drug Product Revenue - Summary of Drug Product Revenue (Detail) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100590 - Disclosure - Equity method investment - Variable Interest Entity - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100600 - Disclosure - Equity method investment - Variable Interest Entity - Summary of Equity Method Investment (Detail) link:presentationLink link:calculationLink link:definitionLink 100610 - Disclosure - Fair Value Measurements - Fair Values of Financial Assets Measured on Recurring Basis (Detail) link:presentationLink link:calculationLink link:definitionLink 100620 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100630 - Disclosure - Leases - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100640 - Disclosure - Leases - Schedule of Lease Assets and Related Lease Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100650 - Disclosure - Leases - Components of Lease Expense (Detail) link:presentationLink link:calculationLink link:definitionLink 100660 - Disclosure - Leases - Schedule of Supplemental Cash Flow Information Related to Leases (Detail) link:presentationLink link:calculationLink link:definitionLink 100670 - Disclosure - Leases - Schedule of Lease Term and Discount Rate (Detail) link:presentationLink link:calculationLink link:definitionLink 100680 - Disclosure - Leases - Schedule of Maturities of Lease Liabilities (Detail) 2 link:presentationLink link:calculationLink link:definitionLink 100690 - Disclosure - Leases - Schedule of Maturities of Lease Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100700 - Disclosure - Balance Sheet Components - Schedule of Cash and Cash Equivalents (Detail) link:presentationLink link:calculationLink link:definitionLink 100710 - Disclosure - Balance Sheet Components - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100720 - Disclosure - Balance Sheet Components - Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments (Detail) link:presentationLink link:calculationLink link:definitionLink 100730 - Disclosure - Balance Sheet Components - Summary of Available for Sale Securities in Unrealized Loss Position, Fair Value and Gross Unrealized Loss By Length of Time Security in Continual Unrealized Loss Position (Detail) link:presentationLink link:calculationLink link:definitionLink 100740 - Disclosure - Balance Sheet Components - Summary of Contractual Maturities of Available-for-Sale Investments (Detail) link:presentationLink link:calculationLink link:definitionLink 100750 - Disclosure - Balance Sheet Components - Schedule of Inventory (Detail) link:presentationLink link:calculationLink link:definitionLink 100760 - Disclosure - Balance Sheet Components - Schedule of Prepaid Expenses and Other Current Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 100770 - Disclosure - Balance Sheet Components - Schedule of Property and Equipment (Detail) link:presentationLink link:calculationLink link:definitionLink 100780 - Disclosure - Balance Sheet Components - Schedule of Accrued and Other Current Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100790 - Disclosure - Balance Sheet Components - Schedule of Other Long-term Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100800 - Disclosure - Liability Related to Sale of Future Royalties - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100810 - Disclosure - Liability Related to Sale of Future Royalties - Schedule of Activity of Liability Related to Sale of Future Revenues (Detail) link:presentationLink link:calculationLink link:definitionLink 100820 - Disclosure - Liability Related to Sale of Future Royalties - Schedule of Revenue Payment Cap Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 100830 - Disclosure - Product Development Obligations - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100840 - Disclosure - Commitments and Contingencies - Summary of Outstanding Non-cancelable Purchase Obligations (Detail) link:presentationLink link:calculationLink link:definitionLink 100850 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100860 - Disclosure - Equity and Stock-based Compensation - Common Stock - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 100870 - Disclosure - Equity and Stock-based Compensation - Summary of Common Stock Reserved for Future Issuance (Detail) link:presentationLink link:calculationLink link:definitionLink 100880 - Disclosure - Equity and Stock-based Compensation - Stock Plans - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 100890 - Disclosure - Equity and Stock-based Compensation - Stock Plans - Summary of Stock Option Transactions (Detail) link:presentationLink link:calculationLink link:definitionLink 100900 - Disclosure - Equity and Stock-based Compensation - Summary of RSU,PRSU and TSR Awards (Detail) link:presentationLink link:calculationLink link:definitionLink 100910 - Disclosure - Equity and Stock-based Compensation - Employee Stock Purchase Plan - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 100920 - Disclosure - Equity and Stock-based Compensation - Schedule of Recorded Stock-Based Compensation Expense (Detail) link:presentationLink link:calculationLink link:definitionLink 100930 - Disclosure - Equity and Stock-based Compensation - Schedule of Assumptions used to Estimate Fair Value of Stock Options Granted and Employee Stock Purchase Plans (Detail) link:presentationLink link:calculationLink link:definitionLink 100940 - Disclosure - Equity and Stock-based Compensation - Stock-Based Compensation - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 100950 - Disclosure - Equity and Stock-based Compensation - Warrants - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 100960 - Disclosure - Equity and Stock based compensation - Schedule of Assumptions used to Estimate Fair Value of TSR Awards (Details) link:presentationLink link:calculationLink link:definitionLink 100970 - Disclosure - Equity and Stock-based Compensation - Non-Controlling Interests and Subsidiary Stock - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 100980 - Disclosure - Net Loss Per Share - Schedule of Weighted Impacts of Outstanding Anti-dilutive Securities Excluded from Calculation of Diluted Net Loss Per Share (Detail) link:presentationLink link:calculationLink link:definitionLink 100990 - Disclosure - Income Taxes - Components of Loss Before Income Taxes (Detail) link:presentationLink link:calculationLink link:definitionLink 101000 - Disclosure - Income Taxes - Schedule of Components of Provision For Income Taxes (Detail) link:presentationLink link:calculationLink link:definitionLink 101010 - Disclosure - Income Taxes - Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate (Detail) link:presentationLink link:calculationLink link:definitionLink 101020 - Disclosure - Income Taxes - Schedule of Significant Components of Deferred Tax Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 101030 - Disclosure - Income Taxes - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 101040 - Disclosure - Income Taxes - Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits (Detail) link:presentationLink link:calculationLink link:definitionLink 101050 - Disclosure - Related Party Transactions - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 101060 - Disclosure - Segment and Geographic Information - Additional information (Detail) link:presentationLink link:calculationLink link:definitionLink 101070 - Disclosure - Segment and Geographic Information - Schedule of Revenue by Geographic Area (Detail) link:presentationLink link:calculationLink link:definitionLink 101080 - Disclosure - Segment and Geographic Information - Schedule of Inventory by Geographic Area (Detail) link:presentationLink link:calculationLink link:definitionLink 101090 - Disclosure - Segment and Geographic Information - Schedule of Inventory by Inventory Ownership (Detail) link:presentationLink link:calculationLink link:definitionLink 101100 - Disclosure - Segment and Geographic Information - Schedule of Long Lived Assets by Geographic Area (Detail) link:presentationLink link:calculationLink link:definitionLink 101110 - Disclosure - Segment and Geographic Information - Summary of Finance and Operating Lease Right of Use Assets by Geographical Location (Detail) link:presentationLink link:calculationLink link:definitionLink 101120 - Disclosure - Segment and Geographic Information - Schedule of Customer Concentration by Collaboration Partners and Distribution Entity (Detail) link:presentationLink link:calculationLink link:definitionLink 101130 - Disclosure - Subsequent Event - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 101140 - Disclosure - Schedule II - Valuation and Qualifying Accounts (Detail) link:presentationLink link:calculationLink link:definitionLink