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Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue (Detail) link:calculationLink link:presentationLink link:definitionLink 100450 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Summary of Revenue Recognized Under the Collaboration Agreements - Additional Information 4 (Detail) link:calculationLink link:presentationLink link:definitionLink 100460 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations Deferred Revenue (Detail) link:calculationLink link:presentationLink link:definitionLink 100470 - Disclosure - Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations Deferred Revenue (Parenthetical) (Detail) link:calculationLink link:presentationLink link:definitionLink 100480 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Summary of Amounts Recognized as Revenue (Detail) link:calculationLink link:presentationLink link:definitionLink 100490 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Summary of Product Revenue, Net (Detail) link:calculationLink link:presentationLink link:definitionLink 100500 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) link:calculationLink link:presentationLink link:definitionLink 100510 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100520 - Disclosure - Collaboration Agreements,License Agreement and Revenues - Drug Product Revenue - Summary of Drug Product Revenue (Detail) link:calculationLink link:presentationLink link:definitionLink 100530 - Disclosure - Collaboration Agreements,License Agreement and Revenues - 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Disclosure - Balance Sheet Components - Schedule of Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 100730 - Disclosure - Balance Sheet Components - Schedule of Accrued and Other Current Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100740 - Disclosure - Balance Sheet Components - Schedule of Other Long-term Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100750 - Disclosure - Product Development Obligations - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100760 - Disclosure - Commitments and Contingencies - Summary of Outstanding Non-cancelable Purchase Obligations (Detail) link:calculationLink link:presentationLink link:definitionLink 100770 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100780 - Disclosure - Equity and Stock-based Compensation - 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Schedule of Weighted Impacts of Outstanding Anti-dilutive Securities Excluded from Calculation of Diluted Net Loss Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 100900 - Disclosure - Income Taxes - Components of Loss Before Income Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 100910 - Disclosure - Income Taxes - Schedule of Components of Provision For Income Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 100920 - Disclosure - Income Taxes - Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 100930 - Disclosure - Income Taxes - Schedule of Significant Components of Deferred Tax Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 100940 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100950 - Disclosure - Income Taxes - Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits (Detail) link:calculationLink link:presentationLink link:definitionLink 100960 - Disclosure - Related Party Transactions - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100970 - Disclosure - Segment and Geographic Information - Additional information (Detail) link:calculationLink link:presentationLink link:definitionLink 100980 - Disclosure - Segment and Geographic Information - Schedule of Revenue by Geographic Area (Detail) link:calculationLink link:presentationLink link:definitionLink 100990 - Disclosure - Segment and Geographic Information - Schedule of Inventory by Geographic Area (Detail) link:calculationLink link:presentationLink link:definitionLink 101000 - Disclosure - Segment and Geographic Information - Schedule of Inventory by Inventory Ownership (Detail) link:calculationLink link:presentationLink link:definitionLink 101010 - Disclosure - Segment and Geographic Information - Schedule of Long Lived Assets by Geographic Area (Detail) link:calculationLink link:presentationLink link:definitionLink 101020 - Disclosure - Segment and Geographic Information - Summary of Finance and Operating Lease Right of Use Assets by Geographical Location (Detail) link:calculationLink link:presentationLink link:definitionLink 101030 - Disclosure - Segment and Geographic Information - Schedule of Customer Concentration by Collaboration Partners and Distribution Entity (Detail) link:calculationLink link:presentationLink link:definitionLink 101040 - Disclosure - Schedule II - Valuation and Qualifying Accounts (Detail) link:calculationLink link:presentationLink link:definitionLink